Richard Paul Woychik Curriculum Vitae

CURRICULUM VITAE

Richard Paul Woychik

Address and Phone

NIEHS

111 T.W. Alexander Dr.

Bldg. 101, B246

P.O. Box 12233, MD B2-06

Research Triangle Park, NC 27709

Rick.Woychik@nih.gov

221 Mill Race Dr.

Chapel Hill, NC 27514

woychik@roadrunner.com

Education

1984 Ph.D. Case Western Reserve University, Cleveland, OH.

1978 M.S. University of Wisconsin, Madison, WI.

1977 B.S. University of Wisconsin, Madison, WI.

Professional Appointments

Jun 2020-Present Director, National Institute of Environmental Health

Sciences (NIEHS) & National Toxicology Program (NTP)

Oct 2019-Jun 2020 Acting Director, NIEHS, NTP

Feb 2011-Oct 2019 Deputy Director, NIEHS

Aug 2002- Jan 2011 President and Chief Executive Officer, The Jackson

Laboratory, Bar Harbor, ME

Jan 2001 – Aug. 2002 Chief Scientific Officer, Lynx Therapeutics, Hayward, CA.

Dec 1998 – Dec 2000 Senior Director, Parke-Davis Laboratory of Molecular

Genetics, Alameda, CA.

Dec 1998 – 2002 Adjunct Professor, Dept. of Pediatrics, Case Western

Reserve University, Cleveland, OH.

Dec 1998 – 2003 Adjunct Professor, Dept. of Pharmacology, Case Western

Reserve University, Cleveland, OH.

Aug 1997 – Nov 1998 Professor and Vice Chairman for Research, Dept. of

Pediatrics, Case Western Reserve University, Cleveland,

OH.

Oct 1997 – Nov 1998 Professor, Dept. of Genetics, Case Western Reserve

University, Cleveland, OH.

Oct 1997 – Nov 1998 Professor, Dept. of Pharmacology, Case Western Reserve

University, Cleveland, OH.

1992 – 2002 Adjunct Professor, Dept. of Pathology, College of

Veterinary Medicine, University of Tennessee, Knoxville,

TN.

1996 - July 1997 Director, Office of Functional Genomics, Oak Ridge

National Laboratory, Oak Ridge, TN

1996 - 1997 Research Professor, College of Arts and Sciences, Dept. of

Biology, University of Tennessee, Knoxville, TN.

1995 - 1996 Head, Mammalian Genetics Section, Oak Ridge National

Laboratory, Oak Ridge, TN

1989 - 1997 Adjunct Associate Professor, School of Biomedical

Sciences at the Oak Ridge National Laboratory, University

of Tennessee, Knoxville, TN.

1987 - 1997 Senior Research Scientist, Mammalian Genetics Section,

Life Sciences Division, Oak Ridge National Laboratory,

Oak Ridge, TN.

1984 - 1987 Postdoctoral Fellow, Department of Genetics, Harvard

Medical School, Boston, Massachusetts. Preceptor: Dr.

Philip Leder.

1983 - 1984 Postdoctoral Researcher, Department of Molecular Biology

and Microbiology, Case Western Reserve University,

Cleveland, Ohio. Preceptor: Dr. Fritz Rottman

Military Service

United States Naval Reserve, 1972-1978.

Honors and Awards

Postdoctoral Fellowship, The Jane Coffin Childs Memorial Fund, 1984-1985,

Postdoctoral Fellowship, Howard Hughes Medical Institute, 1986.

Significant Event Award, 1989, Oak Ridge National Laboratory,

Significant Event Award, 1992, Oak Ridge National Laboratory,

Oak Ridge National Laboratory, Publication Award, 1994.

Professional Service

Editorial Boards

Mutation Research – Reviews, 2008-2014.

Mutation Research, 1996-2003.

Technology Transfer Tactics, 5/2007-2009.

Principal Investigator Advisor, 2009-2011.

Professional Societies

American Association for the Advancement of Science

International Mammalian Genome Society

Society of Toxicology

Environmental Mutagenesis and Genomics Society

Publications

1. Revzin, A. and R.P. Woychik. Quantitation of the interaction of Escherichia coli

RNA polymerase holoenzyme with double-helical DNA using a

thermodynamically rigorous centrifugation method. Biochemistry 20:250-256,

1981.

2. McCorquodale, D.J., C.W. Chen, M.K. Joseph, and R.P. Woychik. Modification

of RNA polymerase from Escherichia coli by pre-early gene products of

bacteriophage T5. J. Virol. 40:958-962, 1981.

3. Sasavage, N.L., M. Smith, S. Gillam, R.P. Woychik, and F.M. Rottman.

Variation in the polyadenylation site of bovine prolactin mRNA. Proc. Natl.

Acad. Sci. 79:223-227, 1982.

4. Woychik, R.P., S.A. Camper, R.L. Lyons, S. Horowitz, E.C. Goodwin, and F.M.

Rottman. Cloning and nucleotide sequencing of the bovine growth hormone

gene. Nucleic. Acids Res. 10:7197-7210, 1982.

5. Nilson, J.H., A.R. Thomason, M.T. Cserbak, C.L. Moncam, and R.P. Woychik.

Nucleotide sequence of a cDNA for the common a subunit of the bovine pituitary

glycoprotein hormones. J. Biol. Chem. 258:4679-4682, 1982.

6. Rottman, F.M., S.A. Camper, and R.P. Woychik. Role of posttranscriptional

mRNA modification in the maintenance of eucaryotic mRNA levels. Proceedings

Alfred Benzon Symposium 19 Gene Expression, Munksgaard, Copenhagen.

7. Camper, S.A., D.N. Luck, Y. Yao, R.P. Woychik, R.G. Goodwin, R.H. Lyons,

and F.M. Rottman. Characterization of the bovine prolactin gene. DNA 3:237-

249, 1984.

8. Woychik, R.P., R.H. Lyons, L. Post, and F.M. Rottman. Requirement for the 3'

flanking region of the bovine growth hormone gene for accurate polyadenylation.

Proc. Natl. Acad. Sci. 81:3944-3948, 1984.

9. Desrosiers, R.C., J. Kamine, A. Bakker, D. Silva, R.P. Woychik, D.D. Sakai, and

F.M. Rottman. Synthesis of bovine growth hormone in primates by using a

Herpes virus vector. Mol. Cell. Biol. 5:2796-2803, 1985.

10. Woychik, R.P., T.A. Stewart, L.G. Davis, P. D'Eustachio, and P. Leder. An

inherited limb deformity created by insertional mutagenesis in a transgenic

mouse. Nature 318:36-40, 1985.

11. Pfarr, D., L. Rieser, R.P. Woychik, F. Rottman, M. Rosenberg, and M. Reff.

Differential effects of polyadenylation regions on gene expression in mammalian

cells. DNA 5:115-122, 1986.

12. Woychik, R. P., B. R. Beatty, and W. L. McKinney, Jr. Insertional mutagenesis

in transgenic mice. In: Multilevel Health Effects Research: From Molecules to

Man, ed. by J.F. Park and R. A. Pelroy. Battele Press, Columbus, Ohio, pp. 87-

90, 1989.

13. Woychik, R. P., W. M. Generoso, L. B. Russell, K. T. Cain, N. L. A. Cacheiro, S.

J. Bultman, P. B. Selby, M. E. Dickinson, B. L. M. Hogan and J. C. Rutledge.

Molecular and genetic characterization of a radiation-induced structural

rearrangement in mouse chromosome 2 causing new mutations at the limb

deformity and agouti loci. Proc. Natl. Acad. Sci. 87:2588-2592, 1990.

14. Woychik, R. P., B. R. Beatty, W. L. McKinney, D. K. Andreadis, A. J. Chang and

P. E. Barker. Insertional mutagenesis in transgenic mice. In: Banbury Report 34:

Biology of Mammalian Germ Cell Mutagenesis, Cold Spring Harbor Laboratory

press, pp. 377-381, 1990.

15. Van der Meer-de Jong, R., M. E. Dickinson, R. P. Woychik, L. Stubbs, C.

Hetherington & B. L. M. Hogan. Location of the gene involving the small eye

mutation on mouse chromosome 2 suggests homology with human aniridia 2

(AN2). Genomics 7:270-275, 1990.

16. Maas, R. L., R. Zeller, R. P. Woychik, T. F. Vogt and P. Leder. Formin encoding

transcripts are disrupted in two mutant limb deformity alleles. Nature 346:853-

855, 1990.

17. Woychik, R. P., D. Maas, R. Zeller, T. F. Vogt, and P. Leder. The formins: a

novel class of proteins deduced from the variable transcripts of the limb deformity

gene. Nature 346:850-853, 1990.

18. Jacobson, K.B., H. F. Arlinghaus, H. W. Schmitt, R. A. Sachleben, G. M. Brown,

N. Thonnard, F. V. Sloop, R. S. Foote, F. W. Larimer, R. P. Woychik, M. W.

England, K. L. Burchett, and D. A. Jacobson. The use of stable isotopes for DNA

sequencing. Genomics 9:51-59, 1991.

19. Arlinghaus, H.F, N. Thonnard, M.T. Sparr, R. A. Sachleben, F.W. Larimer, R. S.

Foote, R. P. Woychik, G. M. Brown, F. V. Sloop, and K. B. Jacobson. Potential

Application of Sputter-Initiated Resonance Ionization spectroscopy for DNA

sequencing. Anal. Biochem. 63:402-407, 1991.

20. Bultman, S., L. B. Russell, G. A. Gutierrez-Espeleta, and R. P. Woychik.

Molecular characterization of a region of DNA associated with mutations at the

agouti locus in the mouse. Proc. Natl. Acad. Sci. 88:8062-8066, 1991.

21. Sachleben, R.A., G. M. Brown, F. V. Sloop, H. F. Arlinghaus, R. S. Foote, F. W.

Larimer, R. P. Woychik, N. Thonnard, N., and K. B. Jacobson. Resonance

ionization spectroscopy for multiplex sequencing of tin-labeled DNA. Genet.

Anal. Tech. and Applications 8(6):167-170, 1991.

22. Furth, P.A., L. Hennighausen, C. Baker, B.R. Beatty, and R.P. Woychik. Utility

of the human cytomegalovirus promoter/ enhancer in transgenic mice. Nucleic

Acids Res. 19(22):6205-6208, 1991.

23. Brown GM, Allison DP, Warmack RJ, Jacobson KB, Larimer FW, Woychik RP,

Carrier WL. Electrochemically induced adsorption of radio-labeled DNA on gold and

HOPG substrates for STM investigations. Ultramicroscopy 38(3-4):253-64, 1991.

PubMed PMID: 1785142.

24. Allison, D.A., R.J. Warmack, L.A. Bottomley, T. Thundat, G.M. Brown, R.P.

Woychik, J.J. Schrick, and K.B. Jacobson, T.L. Ferrell. Scanning tunneling

microscopy of DNA: A novel technique using radiolabeled DNA to evaluate

chemically mediated attachment of DNA to surfaces. Ultramicroscopy 42:1088-

1094, 1992.

25. Allison, D.A., L.A. Bottomley, T. Thundat, G.M. Brown, R.P. Woychik, J.J.

Schrick, K.B. Jacobson, and R.J. Warmack. Immobilization of deoxyribonucleic

acid for scanning probe microscopy. Proc. Natl. Acad. Sci. 89:10129-10133,

1992.

26. Bultman, S.J., E.J. Michaud, and R.P. Woychik. Characterization of the mouse

agouti locus. Cell 71:1195-1204, 1992.

27. Michaud, E.J., S.J. Bultman, L.J. Stubbs, and R.P. Woychik. The embryonic

lethality of homozygous lethal yellow mice (A

) is associated with the

disruption of a novel RNA-binding protein. Genes & Dev. 7:1203-1213, 1993.

28. Woychik, R.P., Wassom, J.S., Kingsbury, D., Jacobson, D.A. TBASE: a

computerized database for transgenic animals and targeted mutations. Nature.

363:(6427):375-6, 1993. Erratum in: Nature. 363:(6430):656, 1993. PubMed PMID:

8497324.

29. Bultman, S.J., M.L. Klebig, E.J. Michaud, H.O. Sweet,

M.T. Davisson, and R.P.

Woychik.

Molecular analysis of reverse mutations from nonagouti (a) to black-

and-tan (a

) and white-bellied agouti (A

) reveals alternate forms of agouti

transcripts. Genes & Dev. 8:481-490, 1994.

30. Michaud, E.J., S.J. Bultman, M.L. Klebig, M.J. van Vugt, L.J. Stubbs, L.B.

Russell, and R.P. Woychik. A molecular model for the genetic and phenotypic

characteristics of the mouse lethal yellow (A

) mutation. Proc. Natl. Acad. Sci.

91:2562-2566, 1994.

31. Moyer, J.M., M.J. Lee-Tischler, H.Y. Kwon, J.J. Schrick, E.D. Avner, W.E.

Sweeney, V.L. Godfrey, N.L.A. Cacheiro, J.E. Wilkinson, and R.P. Woychik.

Candidate gene associated with a mutation causing recessive polycystic kidney

disease in mice. Science 264:1329-1333, 1994.

32. Kwon, H.Y., S.J. Bultman, C. Löffler, W. Chen, P.J. Furdon, J.G. Powell, A. Usala,

W.O. Wilkinson, I. Hansman, and R.P. Woychik. Molecular structure and

chromosomal mapping of the human homolog of the agouti gene. Proc. Natl. Acad.

Sci 91:9760-9764, 1994.

33. Michaud, E.J., M.J. van Vugt, S.J. Bultman, H.O. Sweet, M.T. Davisson, and R.P.

Woychik. Differential expression of a new dominant agouti allele (A

iapy

) is

correlated with methylation state and is influenced by parental lineage. Genes &

Dev. 8:1463-1472, 1994. PubMed PMID: 7926745.

34. Woychik, R.P. Transgenic mice in developmental toxicology. In: Male-Mediated

Developmental Toxicology, ed. by D.R. Mattison and A.F. Olshan. Plenum

Publishing, New York, N.Y., 1994.

35. Lu, D., D. Willard, I.R. Patel, S. Kadwell, L. Overton, T. Kost, M. Luther, W. Chen,

R.P. Woychik, W.O. Wilkison, and R.D. Cone. Agouti protein is an antagonist of the

melanoycte stimulating hormone receptor. Nature 371:799-802, 1994.

36. Shelby, M.D., L.B. Russell, R.P. Woychik, J.W. Allen, L.M. Wiley, and J.B. Favor.

Laboratory research methods in male-mediated developmental toxicity. In: Male-

Mediated Developmental Toxicity, ed. by D.R. Mattison and A.F. Olshan. Plenum

Press, New York, N.Y., pp. 379-384, 1994.

37. Woychik, R.P., J.E. Wilkinson, J.H. Moyer, M.J. Lee-Tischler, H.Y. Kwon, J.J.

Schrick, B. Yoder, E.D. Avner, W.E. Sweeney, and V.L. Godfrey. Insertional

Mutagenesis and PKD. Kid. International 47(3):732, 1995.

38. Schrick, J.J., M.E. Dickinson, B.L.M. Hogan, P.B. Selby, and R.P. Woychik.

Molecular and phenotypic characterization of a new mouse insertional mutation

that causes a defect in the distal vertebrae of the spine. Genetics 140:1061-1067,

1995.

39. Schrick, J.J., L. Onuchic, S.T. Reeders, J.R. Korenberg, X.N. Chen, J.H. Moyer,

J.E. Wilkinson, and R.P. Woychik. Characterization of the human homologue of

the mouse Tg737 candidate polycystic kidney disease gene. Human Mol. Genet.

4:559-567, 1995.

40. Onuchic, L.F., J.J. Schrick, J. Ma., T. Hudson, L.M. Guay-Woodford, K. Zerres, R.P.

Woychik, and S.T. Reeders. Sequence analysis of the human hTg737 gene and its

polymorphic sites in patients with autosomal recessive polycystic kidney disease.

Mammalian Genome 6:805-808, 1995.

41. Klebig, M. L., J.E. Wilkinson, J.G. Geisler, and R.P. Woychik. Ectopic expression of

the agouti gene in transgenic mice causes obesity, features of Type II diabetes, and

yellow fur. Proc. Natl. Acad. Sci. 92:4728-4732, 1995.

42. Zemel, M.B., J.H. Kim, R.P. Woychik, E.J. Michaud, S.H. Kadwell, I.R. Patel, L.

Overton, and W.O. Wilkison. Agouti regulation of intracellular calcium: role in the

insulin resistance of (A

) viable yellow mice. Proc. Natl. Acad. Sci. 92:4733-4737,

1995.

43. Yoder, B.K., W.G. Richards, W.E. Sweeney, J.E. Wilkinson, E.D. Avner, and R.P.

Woychik. Insertional mutagenesis and molecular analysis of a new gene associated

with polycystic kidney disease. Proc. Assoc. Am. Phy. 107: 313-323, 1995.

44. Culiat, C.T., L.J. Stubbs, R.P. Woychik, L.B. Russell, D.K. Johnson, and E.M.

Rinchik. Deficiency of the 3 subunit of the type A -aminobutyric acid receptor

causes cleft palate in mice. Nature Genetics 11:344-346, 1995.

45. Doktycz, M.J., G.B. Hurst, S. Habibi-Goudarzi, S.A. McLuckey, K. Tang, C.H. Chen,

M. Uziel, K.B. Jacobson, R.P. Woychik and M.V. Buchanan. Analysis of

polymerase chain reaction-amplified DNA products by mass spectrometry using

matrix-assisted laser desorption and electrospray: current status. Anal. Biochem.

230:205-214, 1995.

46. Klebig, M. L., J.E. Wilkinson, and R.P. Woychik. Molecular analysis of the mouse

agouti gene and the role of dominant agouti-locus mutations in obesity and insulin

resistance. In: Molecular and Genetic Aspects of Obesity - Pennington Nutrition

Series, Vol. 5, ed. by G. Bray and D. York, Louisiana State University Press, Baton

Rouge, Louisiana, 1996.

47. Jones, B.H., J.H. Kim, M.B. Zemel, R.P. Woychik, E.J. Michaud, W.O. Wilkison,

and N. Moustaid. The agouti gene product upregulates expression of adipose fatty

acid synthetase and stearoyl-CoA desaturase genes. A possible role for [Ca

]i in

agouti signaling. Am. J. Physiol. 270:E192-E196, 1996.

48. Yoder, B.K., W.G. Richards, C. Sommardahl, W.E. Sweeney, E.J. Michaud, J.E.

Wilkinson, E.D. Avner, and R.P. Woychik. 1996. Functional correction of the renal

defects in a mouse model for ARPKD through expression of the cloned wild-type

Tg737 gene. Kidney International, 50:1240-1248, 1996.

49. Richards, W.G., B.K. Yoder, R.J. Isfort, P.G. Detilleux, C. Foster, N. Neilsen, R.P.

Woychik, and J.E. Wilkinson. Oval cell proliferation associated with the murine

insertional mutation TgN737Rpw. Am. J. Path. 149: 1919-1930, 1996.

50. Kim, J.H., R. Mynatt, J.W. Moore, R.P. Woychik, N. Moustaid, and M.B. Zemel. The

effects of calcium channel blockade on agouti-induced obesity. FASEB J. 10: 1646-

1652, 1996.

51. Mynatt, R.L., R.J. Miltenberger, M.L. Klebig, L.L. Keifer, J-H Kim, M.B. Zemel,

J.E. Wilkinson, W.O. Wilkison, and R.P. Woychik. Analysis of the function of the

agouti gene in obesity and diabetes. In: Proceedings International Business

Communications 2nd Annual International Symposium: Obesity, Advances in

Understanding and Treatment. Ed. by L.A. Weston. International Business

Communications, Southborough, Massachusetts, 1996.

52. Mynatt, R.L., R.J. Miltenberger, M.L. Klebig, M.B. Zemel, J.E. Wilkinson, W.O.

Wilkison, and R.P. Woychik. Combined effects of insulin treatment and adipose

tissue-specific agouti expression on the development of obesity. Proc. Natl. Acad.

Sci. 94:919-922, 1997.

53. Richards, W.G., B.K. Yoder, R.J. Isfort, P.G. Detilleux, C. Foster, N. Neilsen, R.P.

Woychik, and J.E. Wilkinson. Isolation and characterization of liver epithelial cell

lines from wild-type and mutant TgN737Rpw mice. Am. J. Path. 150:1189-1197,

1997.

54. Sommardahl, C.S., R.P. Woychik, W.E. Sweeney, E.D. Avner, and J.E. Wilkinson.

Efficacy of taxol in the orpk mouse model of polycystic kidney disease. Pediatric

Nephrol. 11:728-733, 1997.

55. Yoder, B.K., W.G. Richards, C. Sommardahl, W.E. Sweeney, E.J. Michaud, J.E.

Wilkinson, E.D. Avner, and R.P. Woychik. Differential rescue of the renal and

hepatic disease in an ARPKD mouse mutant: A new model to study the liver lesion.

Am J. Pathol. 150:2231-2241, 1997.

56. Miltenberger, R.J., R.L. Mynatt, J.E. Wilkinson, and R.P. Woychik. Role of the

agouti gene in obesity. J. Nutrition. 127:1902S-1907S, 1997.

57. Isfort, R.J., D.B. Cody, C.J. Doersen, W.G. Richards, B.K. Yoder, J.E. Wilkinson,

L.D. Kier, R.L. Jirtle and R.P. Woychik. The tetratricopeptide repeat containing

Tg737 gene is a liver neoplasia tumor suppressor gene. Oncogene 15:1797-1803,

1997.

58. Isfort, R.J., D.B. Cody, S.B. Stuard, C.J. Randall, C. Miller, G.M. Ridder, C.J.

Doersen, W.G. Richards, B.K. Yoder, J.E. Wilkinson, and R.P. Woychik. The

combination of epidermal growth factor and transforming growth factor-beta induces

novel phenotypic changes in mouse liver stem cell lines. J. Cell Sci. 110:3117-3129,

1997.

59. Woychik, R.P., B. Hogan, S. Bryant, G. Eichele, D. Kimelman, D. Noden, G.

Schoenwolf, C. Wright. Pattern Formation. Reproductive Toxicology 11:339-344,

1997.

60. Justice, M.J., B. Zheng, R.P. Woychik, and A. Bradley. Using targeted large deletions

and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the

mammalian genome. Methods 13:423-436, 1997.

61. Michaud, E.J., R.L. Mynatt, R.J. Miltenberger, M.L. Klebig, J.E. Wilkinson, M.B.

Zemel, W.O. Wilkison, and R.P. Woychik. Role of the agouti gene in obesity. J.

Endocrinol. 155:207-209, 1997.

62. Kim, J.H., L.L. Kiefer, Woychik, R.P., Wilkison, W.O., Truesdale, A., Ittoop, O.,

Willard, D., Nichols, J., and Zemel, M.B. Agouti regulation of intracellular calcium:

role of melanocortin receptors. Am . J. Physiol. 272:E379-E384, 1997.

63. Isfort, R.J., D.B. Cody, W.G. Richards, B.K. Yoder, J.E. Wilkinson, and R.P.

Woychik. Characterization of growth factor responsiveness and alterations in growth

factor homeostasis involved in the tumorigenic conversion of mouse oval cells.

Growth Factors 15:81-94, 1998.

64. Richards, W.G., W.E. Sweeney, B.K. Yoder, J.E. Wilkinson, R.P.Woychik, and E.D.

Avner. Epidermal growth factor receptor activity mediates renal cyst formation in

polycystic kidney disease. J. Clin. Invest. 101:935-939, 1998.

65. Khrebtukova, I., E.J. Michaud, C.M. Foster, K.L. Stark, Garfinkel, D.J., and R.P.

Woychik. Utilization of microhomologous recombination in yeast to generate

targeting constructs for mammalian genes. Mutation Res. 401:11-25, 1998.

66. Murcia, N.S., R.P. Woychik, and E.D. Avner. The molecular biology of polycystic

kidney disease. Pediatric. Nephrol. 12:721-6, 1998.

67. Woychik, R.P., M.L. Klebig, M.J. Justice, T.R. Magnuson, and E.D. Avner.

Functional genomics in the post-genome era. Mutation Res. 400:3-14, 1998.

68. Woychik, R.P. and K. Alagramam. Insertional mutagenesis in transgenic mice

generated by the pronuclear microinjection procedure. International Journal of

Developmental Biology 42:1009-17, 1998.

69. Hansen, L.A., D.E. Malarkey, J.E. Wilkinson, M. Rosenberg, R.P. Woychik, and

R.W. Tennant. Effect of the viable-yellow (A

) agouti allele on skin tumorigenesis

and humoral hypercalcemia in v-Ha-ras transgenic TG.AC mice. Carcinogenesis

19:1837-1845, 1998.

70. Davis, A.P., Woychik, R.P., and Justice, M.J. Effective chemical mutagenesis is

FVB/N mice requires low doses of ethylnitrosourea. Mammalian Genome 10:308-10,

1999.

71. Miltenberger, R.J., R.L. Mynatt, B.D. Bruce, W.O. Wilkison, R.P.Woychik, and E.J.

Michaud. An agouti mutation lacking the basic domain induces yellow pigmentation

but not obesity in transgenic mice. PNAS 96(15):8579-8584, 1999.

72. Alagramam, K.N., H. Kwon, N.L.A. Cacheiro, L.Stubbs, C.G. Wright, L.C. Erway,

and R.P. Woychik. Molecular and phenotypic characterization of a new mouse

insertional mutation that causes sensorineural deafness and vestibular defects.

Genetics 152:1691-1699, 1999.

73. Khrebtukova, I., A. Kuklin, R.P. Woychik, and E.J. Michaud. Alternative processing

of the human and mouse raly genes. Biochim. Biophys. ACTA 1447:107-112, 1999.

74. Avner, E.D., R.P.Woychik, K.M. Dell, and W.E. Sweeney. Cellular pathophysiology

of cystic kidney disease: insight into future therapies. Int. J. Dev. Bio. 43:457-461,

1999.

75. Khrebtukova I I, Michaud EJ, Foster CM, Stark KL, Garfinkel DJ, Woychik RP.

Corrigendum to: 'Utilization of microhomologous recombination in yeast to generate

targeting constructs for mammalian genes'. Mutat Res. 423(1-2):191, 1999. PubMed

PMID: 10029697.

76. Murcia, N.S., W.G. Richards, B.K. Yoder, M.L. Mucenski, J.R. Dunlap, and R.P.

Woychik. The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-

right axis determination. Development 127:2347-2355, 2000.

77. Chen, Y., D. Yee, K. Dains, A. Chatterjee, J. Cavalcoli, E. Schneider, J. Om,

R.P.Woychik, and T. Magnuson. Genotype-based screen for ENU-induced mutations

in mouse embryonic stem cells. Nat. Genet. 24:314-317, 2000. PubMed PMID:

10700191.

78. Alagramam, K.N., J. Zahorsky-Reeves, C.G. Wright, K.S. Pawlowski, L.C. Erway, L.

Stubbs, and R.P. Woychik. Neuroepithelial defects of the inner ear in a new allele of

Ames Waltzer. Hearing Res. 148:181-191, 2000.

79. Colitz, C.M.H., D.E. Malarkey, R.P. Woychik, and J. E. Wilkinson. Persistent

hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous in

transgenic line TgN3261Rpw. Vet. Pathol. 37:422-427, 2000.

80. Alagramam, K.N., C.L. Murcia, H.Y. Kwon, K.S. Pawlowski, C.G. Wright, and R.P.

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81. Murcia, CL. and R.P. Woychik. Expression of Pcdh15 in the inner ear, nervous

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82. Sommardahl, C., M. Cottrell, J.E. Wilkinson, R.P. Woychik, and D.K. Johnson.

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83. Miltenberger, R.J., K. Wakamatsu, S. Ito, R.P. Woychik, L.B. Russell, and E.J.

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84. Alagramam, K. N., Yuan, H., Kuehn, M.H., Murcia, C.L., Wayne, S., Srisailpathy,

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R.P., Smith, R.J., Hagemen, G.S. Mutations in the novel protocadherin PCDH15

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85. Reinartz, J., Bruyns, E., Lin, J.Z., Burcham, T., Brenner, S., Bowen, B., Kramer,

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86. Woychik, R.P., Brenner, S., Burcham, T., Corcoran, K., Albrecht, G., and Russell, N.

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87. Woychik, R.P and O’Brien, T. Our small relative. Nat. Genet. 33:3-4, 2003.

88. Zhang, Q., Murcia, N.S., Chittenden, L.R., Richards, W.G., Michaud, E.J., Woychik,

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89. Kuklin, A.I., Mynatt, R.L., Klebig, M.L., Kiefer, L.L., Wilkison, W.O., Woychik,

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90. Austin, C.P., Battey, J.F., Bradley, A, Bucan, M, Capecchi, M, Collins, F.S., Dove,

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T.R., Joyner, A., Koller, B.H., Lloyd, K.C., Magnuson, T., Moore, M.W., Nagy, A.,

Pollock, J.D., Roses, A.D., Sands, A.T., Seed, B., Skarnes, W.C., Snoddy, J., Soriano,

P., Stewart, D.J., Stewart, F., Stillman, B., Varmus, H., Varticovski, L., Verma, I.M.,

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91. Kuklin, A.I., Mynatt, R.L., Klebig, M.L., Kiefer, L.L, Wilkison, W.O., Woychik,

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mice promotes liver carcinogenesis in the absence of obesity and diabetes. Mol.

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92. Woychik, R.P., Bult, C. Functional Analysis of Genes. In: Encyclopedia of Genetics,

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93. Gridley, T., Woychik, R. Laser surgery for mouse geneticists. Nat Biotechnol. 25:59-

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94. Wyrobek, A.J., Mulvihill, J.J., Wassom, J.S., Malling, H.V., Shelby, M.D., Lewis,

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Woychik, R.P., Bishop, J.B. Assessing human germ-cell mutagenesis in the

Postgenome Era: a celebration of the legacy of William Lawson (Bill) Russell.

Environ. Mol. Mutagen. 48:71-95, 2007.

95. Carlin, D.J., Rider, C.V., Woychik, R., Birnbaum, L.S. Unraveling the health effects

of environmental mixtures: an NIEHS priority. Environmental Health Perspectives

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96. Martínez-Reyes, I., Diebold, L.P., Kong, H., Schieber, M., Huang, H., Hensley, C.T.,

Mehta, M.M., Wang, T., Santos, J.H., Woychik, R., Dufour, E., Spelbrink, J.N.,

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97. Wang, T., Santos, J.H., Feng, J., Fargo, D.C., Shen, L., Riadi, G., Keeley, E., Rosh,

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PLoS One. 11(7): e0159028. 2016. PMID: 27415830. *Co-corresponding authors.

98. Lozoya, O.A., Martinez-Reyes, I., Wang, T., Grenet, D., Bushel, P., Li, J., Chandel,

N., Woychik, R.P.*, and Santos, J.H.* (2018) Mitochondrial nicotinamide adenine

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methionine metabolism and nuclear DNA methylation. PLoS Biol 16(4): e2005707.

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99. Lozoya, O.A., Santos, J.H., and Woychik, R.P. A Leveraged Signal-to-Noise Ratio

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100. Collman, G.W., Berridge, B.R., Hall, J.E., Woychik, R., Zeldin, D.C., Birnbaum,

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101. Lozoya, O.A., Wang, T., Grenet, D., Wolfgang, T.C., Sobhany, M., Ganini da

Silva, D., Riadi, G., Chandel, N., Woychik, R.P.*, and Santos, J.H.* Mitochondrial

acetyl-CoA reversibly regulates locus-specific histone acetylation and gene

expression. Life Science Alliance. 2 (1) e201800228. 2019. *Co-corresponding

authors.

102. Lozoya, O., Xu, F., Grenet, D., Wang, T., Grimm, S., Godfrey, V., Waidyanatha,

S., Woychik, R.P.*, and Santos, J.H.* Single nucleotide resolution analysis reveals

pervasive and long-lasting DNA methylation remodeling caused by developmental

exposure to a mitochondrial toxicant. Under Review, Cell Reports. *Co-

corresponding authors.

103. Lozoya, O., Grenet, D., Wang, T., Nadalutti, C., Wilson, S., Giorgio, V.,

Debattisti, V., Hassan, P., Hajnoczky, Woychik, R.P.*, and Santos, J.H.* Los of

ATPIF1 remodels the nuclear epigenome and transcriptome. In preparation. *Co-

corresponding authors.

104. Lozoya, O., Grenet, D., Wang, T., D’Aurelio, M., Manfredi, G., Woychik, R.P.*,

and Santos, J.H.* Mutations at different sites of the mitochondrial electron transport

chain lead to diverse epigenetic and transcriptomic outcomes. In preparation. *Co-

corresponding authors.

105. Xu, F., Lozoya, O.A., Wang, T., Grenet, D., Jensen, P., Hernandez, B., Riadi, G.,

Santos, J.H.*, and Woychik, R.P.* A novel brain-specific fusion isoform of Pgc1a

acts as a co-repressor of cerebellar genes and is associated with behavioral changes in

the mouse. In preparation. *Co-corresponding authors.