88 C. Review of Proposals
C.1. Table A. Regulatory Criteria Applicable to Protocol Review as
Defined in PHS Policy and USDA Regulations (continued)
U.S. Government PHS Policy on USDA AWR 9 CFR Part 2,
Principles Humane Care and Use Subpart C
of Laboratory Animals
Principle VI: Animals that would
otherwise suffer severe or
chronic pain or distress that
cannot be relieved should be
painlessly killed at the end of
the procedure or, if appropriate,
during the procedure.
(See C.2.b. Euthanasia)
Principle VII: The living
conditions of animals should be
appropriate for their species and
contribute to their health and
comfort. Normally, the housing,
feeding, and care of all animals
used for biomedical purposes
must be directed by a veterinar-
ian or other scientist trained and
experienced in the proper care,
handling, and use of the species
being maintained or studied. In
any case, veterinary care shall
be provided as indicated.
(See B.2.b. Animal Environment,
B.2.c. Husbandry, and B.3.
Role of the Veterinarian)
Principle VIII: Investigators and
other personnel shall be appro-
priately qualified and experienced
for conducting procedures on
living animals. Adequate arrange-
ments shall be made for their
in-service training, including the
proper and humane care and
use of laboratory animals.
(See C.2.e. Personnel
Qualifications)
IV.C.1.c.: Animals that would
otherwise experience severe
or chronic pain or distress
that cannot be relieved will
be painlessly killed at the end
of the procedure or, if appro-
priate, during the procedure.
IV.C.1.g.: Methods of eutha-
nasia will be consistent with
the recommendations of the
AVMA Panel on Euthanasia,
unless a deviation is justified
for scientific reasons in writ-
ing by the investigator [and
approved by the IACUC].
IV.C.1.d.: The living conditions
of animals will be appropriate
for their species and contribute
to their health and comfort.
The housing, feeding, and
non-medical care of the animals
will be directed by a veterinarian
or other scientist trained and
experienced in the proper care,
handling, and use of the species
being maintained or studied.
IV.C.1.e.: Medical care for
animals will be available and
provided as necessary by a
qualified veterinarian.
IV.C.1.f.: Personnel conducting
procedures on the species being
maintained or studied will be
appropriately qualified and
trained in those procedures.
§2.31(d)(1)(v): Animals that would
otherwise experience severe
or chronic pain or distress that
cannot be relieved will be pain-
lessly euthanized at the end
of the procedure or, if appro-
priate, during the procedure.
§2.31(d)(1)(xi): Methods of
euthanasia used must be in
accordance with the definition
of the term set forth in 9 CFR
part 1, §1.1 of this subchapter,
unless a deviation is justified
for scientific reasons, in writ-
ing, by the investigator.
§2.31(d)(1)(vi): The animals’ living
conditions will be appropriate
for their species in accordance
with part 3 of this subchapter,
and contribute to their health
and comfort. The housing, feed-
ing, and nonmedical care of the
animals will be directed by the
attending veterinarian or other
scientist trained and experienced
in the proper care, handling,
and use of the species being
maintained or studied.
§2.31(d)(1)(vii): Medical care for
animals will be available and
provided as necessary by a
qualified veterinarian.
§2.31(d)(1)(viii): Personnel
conducting procedures on
the species being maintained
or studied will be appropriately
qualified and trained in those
procedures.